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, broke out amongst troops in Italy and rapidly spread across Europe, reaching England and Holland in 1496. In 1500 there was an epidemic of syphilis across Europe and in 1505 it reached China.
(Calendar of Patent Rolls Reign of , later to become Bethlehem Hospital ("Bedlam"), was taken under the patronage and protection of Richard Lacer, mayor of London, and the citizens of London.
Ye gave him eyes, Nasatyas, Wonder-Workers, Physicians, that he saw with sight uninjured. (See Arabic translations of Galen, commentaries by Arab physicians, and sometimes the original Greek, were translated into Latin.
These became the basis of medical education in the European universities that started in the late 1201 St Nicholas Hospital in Carlisle claims to have been treating lepers in 1201 - to have passed to the City as a (general) hospital in 1477 - Some local historians link this forward to the opening of a fever hospital in 1809 and the Cumberland Infirmary in 1828.
See "In this city, there are many and very important pious and charitable initiatives.
However, one very necessary one is lacking, that is, a hospital or house where the innocent and frenzied would be drawn together because many poor, innocent and frenzied people wander through this city.
By the fourteenth century (1300) "the main beneficiaries, apart from the Hospital and its staff, were probably poor people who lived locally, rather than the Order of Bethlehem.